| Autor: |
Horstmann, D. M., Paul, J. R., Godenne-McCrea, M., Green, R. H., Opton, E. M., Holtz, A. I., Niederman, J. C. |
| Zdroj: |
JAMA: Journal of the American Medical Association; November 1961, Vol. 178 Issue: 7 p693-701, 9p |
| Abstrakt: |
The effectiveness of an oral polivirus vaccine using Sabin strains was studied among some 350 preschool children beginning in January, 1960. Although 79% of the children had previously received 3 or more doses of killed virus vaccine, a relatively high per cent lacked antibody to one or more types, and 22% of 348 children were triple negatives. The oral vaccine was given according to 3 different dosage schedules: each type singly; Type 1 followed by Types 2 and 3 together; and trivalent vaccine twice, 6 weeks apart. The infection and antibody conversion rates were similarly high for all 3 schedules, the overall conversion rates being 95% for Type 1, 98% for Type 2, and 86% for Type 3. The results emphasize the desirability of oral vaccine for young preschool children regardless of previous administration of multiple doses of killed Salk-type vaccine. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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