| Abstrakt: |
Previous studies in this laboratory had shown little difference among 4 commonly used anticoagulants, bishydroxycoumarin, coumadin sodium, phenindione, and diphenadione. Two newer agents, anisindione and acenocoumarol, for which distinct superiority has been claimed, were compared under controlled conditions with two of the earlier drugs, bishydroxycoumarin and diphenadione, in 230 patients. No clinically significant differences that would recommend one agent over the other were observed. Using a large initial loading dose the majority of the patients could be brought into the therapeutic range at 40 hours and maintained at therapeutic levels approximately 85 per cent of the time with any of the drugs. The authors feel that any of the available prothrombinopenic agents, properly handled, is satisfactory for routine use in anticoagulant therapy, and that physicians should be slow to abandon one with which they are experienced. |
