| Autor: |
Einspruch, Burton C., Gonzalez, Virgilio V. |
| Zdroj: |
JAMA: Journal of the American Medical Association; June 1960, Vol. 173 Issue: 7 p809-811, 3p |
| Abstrakt: |
Prolonged parenteral therapy with neomycin sulfate may be accompanied by renal lesions.1 We have studied, by stain and microscopy procedures, lesions ascribed to neomycin which were experimentally induced in the kidneys of rabbits, and we have compared them to lesions found in human autopsy specimens. EXPERIMENTAL STUDIES Five rabbits (average weight 1.7 kg. [4 lb.]) were injected with 35 mg. of neomycin daily in the marginal ear vein. After 30 consecutive days of injections the rabbits were killed, and sections of kidney tissue were immediately fixed in formaldehyde and studied by staining procedures described in the standard textbooks2; minor variations are indicated.Human renal tissues were obtained fresh at autopsy from three patients who had received large amounts of neomycin during the terminal stages of their diseases. These tissues were treated identically to the rabbit specimens. The lipid components of the lesions1 were studied with use of |
| Databáze: |
Supplemental Index |
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