| Autor: |
Price, Alison H., Erf, Lowell, Bierly, James |
| Zdroj: |
JAMA: Journal of the American Medical Association; July 1958, Vol. 167 Issue: 13 p1612-1615, 4p |
| Abstrakt: |
A radioactive isotope of iron was administered to 10 patients by mouth in order that its absorption into the blood might be studied. Each dose consisted of 10 cc. of an aqueous suspension containing 0.1 mc. of Fe59SO4 with 200 mg. of stable ferrous sulfate and 200 mg. of magnesium aluminum hydroxide. The appearance of the isotope in the blood was manifested by a rise in the radioactive disintegration count from an average of 265 counts per minute per 5 cc. sample to figures as high as 582. Counts were made on the whole blood because the serum alone showed very little radioactivity. The daily administration of two uncoated tablets, each containing 200 mg. of ferrous sulfate and 200 mg. of magnesium aluminum hydroxide, was carried out in 27 patients, all of whom had reported nausea and other gastrointestinal symptoms after taking other iron preparations in unspecified doses. In this series no patient experienced nausea, and there was but one case each of diarrhea and abdominal cramps. The presence of the buffer did not prevent the absorption of iron even when the total acidity of the gastric juice was extremely low. The absence of a coating on the tablets was believed to favor early absorption. |
| Databáze: |
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| Externí odkaz: |
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