| Abstrakt: |
A testicular teratocarcinoma occurring in a 35-year-old man was treated initially by surgery and later by irradiation of the inguinal and abdominal regions. Chest films showed an initial absence of pulmonary metastases, but later films showed the gradual appearance of pulmonary lesions until, six months after operation, 12 or 13 such lesions were visible. Administration of nitrofurazone in doses of 0.5 Gm. twice (later three times) a day by mouth was followed by the complete disappearance of some of these nodules. The onset of a severe peripheral neuritis made it necessary to discontinue this treatment. Symptoms of pulmonary involvement recurred, and the chest films revealed an increase in the size and number of the lesions. The patient died of metastases to lungs, liver, brain, pericardium, and regional lymph nodes. This history closely parallels reports by other authors as to the striking therapeutic effects as well as the painful side-effects of nitrofurazone, and indicates the importance of further trials of this drug and its derivatives. |
