| Abstrakt: |
The efficiency of ethoheptazine as an analgesic was investigated in two series of observations. The first series, involving 71 patients with arthritis and other painful conditions, was set up to compare the effects of lactose as a placebo), aspirin, aspirin plus codeine, aspirin plus ethoheptazine, and ethoheptazine alone. The drugs were administered in capsules with certain precautions that prevented both the patient and those who appraised his responses from knowing which of the five kinds of capsules he was receiving. The results showed that aspirin and ethoheptazine were potent analgesics when given singly, and that when they were given together their combined effect was greater than that of either alone. Ethoheptazine 100 mg. alone was more efficient than aspirin 600 mg. alone. The second series, involving 35 patients, was set up to compare the effects of lactose (as placebo), aspirin plus ethoheptazine, and aspirin plus codeine. The results showed that the two mixtures were about equally good and that both were better than the placebo. Ethoheptazine in the dosage used caused less side-effects than did the placebo. This study illustrates two comparative statistical methods. |
