| Abstrakt: |
Apart from a brief historic sketch of the subject of coagulation and the current views as to the more or less theoretic principles underlying it, this paper does not deal with the more intimate physiologic aspects of the question. It is to be regarded rather as a consideration of alleged coagulants from the therapeutic standpoint. THE PROTHROMBINS. Sahli sums up the present views as to coagulation, based in large part on Morowitz's work. He quotes Morowitz as having described two prothrombins, alpha and beta: A-prothrombin, the one evidently studied by Hammarsten, changes into thrombin after activation by lime salts; β-prothrombin is not converted into thrombin in the presence of lime, but the change is brought about through the agency of alkalies, probably also by Schmidt's zymoplastic substance, and according to Morowitz by acids. Hence the apparent contradiction between Schmidt and Hammarsten as to the lime factor, for Schmidt was |
