| Autor: |
Fausti, Stephen A., Henry, James A., Schaffer, Heidi I., Olson, Deanna J., Frey, Richard H., Bagby, Grover C. |
| Zdroj: |
Archives of Otolaryngology-Head & Neck Surgery; June 1993, Vol. 119 Issue: 6 p661-666, 6p |
| Abstrakt: |
• Cisplatin can cause irreversible hearing loss initially detectable as impairment of high-frequency hearing with progression to lower frequencies. Many patients receiving cisplatin are too ill to tolerate lengthy audiometric testing. Therefore, a rapid and sensitive high-frequency monitoring strategy to detect cisplatin-induced ototoxicity is needed. Serial conventional (0.25 to 8 kHz) and high-frequency (≥8 kHz) threshold monitoring was performed in patients receiving cisplatin, resulting in 84% of ears showing hearing loss, of which 71% were detected first in frequencies of 8 kHz or greater. By analysis according to an individualized, specific high-frequency range, early identification of hearing loss occurred in 94% of ears showing change. This five-frequency procedure is a sensitive detector of ototoxicity and is proposed as an alternative monitoring protocol for patients receiving cisplatin who cannot tolerate extended testing.(Arch Otolaryngol Head Neck Surg. 1993;119:661-666) |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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