| Autor: |
JOHNSTON, DANIEL W., JENSEN, WILLIAM B., BYRD, MARY LOU |
| Zdroj: |
Archives of Otolaryngology-Head & Neck Surgery; November 1957, Vol. 66 Issue: 5 p592-593, 2p |
| Abstrakt: |
Severe toxic reactions and fatalities following the use of tetracaine have repeatedly been reported in the literature, and analysis of these reports reveals that practically all of these reactions have occurred after topical application and few, if any, after subcutaneous infiltration or other forms of regional anesthesia (Bonica1).Following the topical application of tetracaine, there is rapid absorption into the circulation, and blood levels are attained that are equal to one-third to one-half those that occur after the same amount of the drug has been rapidly injected intravenously. After the subcutaneous injection of the same dose of tetracaine the blood level is so low that it is unobtainable. These blood level studies were done on dogs by Adriani and Campbell.2 After application of tetracaine to mucous surfaces of the pharynx, larynx, and bronchi peak blood levels were reached within four to six minutes. There was little difference between |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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