| Autor: |
Trouillas, Paul, Serratrice, Georges, Laplane, Dominique, Rascol, André, Augustin, Paul, Barroche, Gérard, Clanet, Michel, Degos, Claude F., Desnuelle, Claude, Dumas, Raymond, Michel, Daniel, Viallet, François, Warter, Jean M., Adeleine, Patrice |
| Zdroj: |
Archives of Neurology; May 1995, Vol. 52 Issue: 5 p456-460, 5p |
| Abstrakt: |
OBJECTIVE: To study the effect of the levorotatory form of 5-hydroxytryptophan on the cerebellar symptoms of Friedreich's ataxia. DESIGN: Cooperative double-blind study of the levorotatory form of 5-hydroxytryptophan vs placebo. SETTING: Twelve centers in research hospitals. Patients: Twenty-six patients were included; 19 completed the study (mean±SD age of patients, 25.9±8.1 years). Of these 19 patients, eight were treated with placebo and 11 were treated with the drug. MAIN OUTCOME MEASURES: A semiquantitative scale for kinetic and static ("postural") cerebellar functions and quantitative measurements of time in standard tests that evaluated stance, speech, writing, and drawing. RESULTS: In the active treatment group, a significant decrease of the kinetic score was observed (P=.03), indicating an improvement in coordination. CONCLUSIONS: These results demonstrated that the levorotatory form of 5-hydroxytryptophan is able to modify significantly the cerebellar symptoms in patients with Friedreich's ataxia. However, the effect is only partial and not clinically major. |
| Databáze: |
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