Propranolol Plasma Levels and Relief of Migraine: Relationship Between Plasma Propranolol and 4-Hydroxypropranolol Concentrations and Clinical Effects

Autor: Cortelli, Pietro, Sacquegna, Tommaso, Albani, Fiorenzo, Baldrati, Anna, D'Alessandro, Roberto, Baruzzi, Agostino, Lugaresi, Elio
Zdroj: Archives of Neurology; January 1985, Vol. 42 Issue: 1 p46-48, 3p
Abstrakt: • The relationship between propranolol and 4-hydroxypropranolol plasma concentrations and relief of migraine was assessed in 17 patients during treatment with oral racemic propranolol hydrochloride in doses of 40 to 240 mg /day. Propranolol decreased the migraine index more than 70% in 13 patients: five patients at a dosage of 40 mg/day, five patients at a dosage of 120 mg/day, and three patients at a dosage of 240 mg/ day. Three patients did not achieve a good improvement of migraine at any of the doses used. The relief of migraine was not directly related to the propranolol and 4-hydroxypropranolol plasma concentrations.
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