| Autor: |
Wyndham, Roger N., Gimenez, Luis, Walker, W. Gordon, Whelton, Paul K., Russell, R. Patterson |
| Zdroj: |
Archives of Internal Medicine; June 1987, Vol. 147 Issue: 6 p1021-1025, 5p |
| Abstrakt: |
• Initial plasma renin activity (PRA) was measured in 213 patients with untreated hypertension before beginning thiazide (chlorothiazide and hydrochlorothiazide) therapy alone to test whether patients with low-renin hypertension exhibited a greater response to diuretic therapy. Diastolic blood pressure response to treatment in the low, mid-range, and high PRA groups did not differ significantly (Δ diastolic blood pressure, -13.6±1.6, -11.6±1.5, and -10.8±2.6 mm Hg, respectively). Moreover, eight subjects with the highest PRA values exhibited the same magnitude of decrease in diastolic blood pressure as did the low PRA group (15.0±4.2 vs 13.6 ±1.6, respectively). This study thus provides no evidence for increased sensitivity to diuretic therapy among patients with low-renin essential hypertension.(Arch Intern Med 1987;147:1021-1025) |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
