Autor: |
McAllister, Russel G., Love, David W., Guthrie, Gordon P., Dominic, Jerome A, Kotchen, Theodore A. |
Zdroj: |
Archives of Internal Medicine; August 1979, Vol. 139 Issue: 8 p879-881, 3p |
Abstrakt: |
Peripheral β-adrenergic receptor sensitivity was characterized in 24 patients with essential hypertension and in 13 agematched normotensive subjects using an isoproterenol hydrochloride bolus dose-response technique. Decreased β-receptor responsiveness to this exogenously administered β-agonist was observed in hypertensive patients; for an equivalent chronotropic effect, higher doses of isoproterenol were required in hypertensive subjects than in normal subjects. Among "normal-renin" hypertensive patients, β-receptor responsiveness was directly related to furosemide-stimulated plasma renin activity (PRA), suggesting that independently stimulated PRA may provide an indirect estimate of endogenous β-receptor sensitivity. Hypertensive patients whose mean arterial pressure fell at least 10 mm Hg after four weeks of treatment with hydrochlorothiazide had even further depression in β-receptor responsiveness, whereas receptor sensitivity was unchanged in patients whose blood pressure was unaffected. Thus, it is unlikely that this decreased receptor responsiveness in patients with untreated essential hypertension is a direct consequence of elevated arterial pressure.(Arch Intern Med 139:879-881, 1979) |
Databáze: |
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Externí odkaz: |
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