| Autor: |
Postlethwaite, Arnold E., Ramsdell, C. Michael, Kelley, William N. |
| Zdroj: |
Archives of Internal Medicine; August 1974, Vol. 134 Issue: 2 p270-275, 6p |
| Abstrakt: |
An anticholinergic agent, glycopyrrolate, produced an increase in the fractional excretion of uric acid of greater than 20% in eight of 19 subjects with hyperuricemia or gout but in none of the 15 normouricemic control subjects. Glycopyrrolate placebo had no effect. A similar uricosuric effect was observed in several subjects following the administration of a second anticholinergic agent, tridihexethyl chloride, but not with the administration of a third agent, L-hyoscyamine. The uricosuric effect of glycopyrrolate and tridihexethyl chloride was not associated with a change in the binding of urate to plasma proteins in vitro. The autonomic nervous system may contribute to the regulation of uric acid excretion in some patients. |
| Databáze: |
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| Externí odkaz: |
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