Recurrence of Glomerulonephritis in the Transplanted Kidney

Autor: Dixon, Frank J., McPhaul, John J., Lerner, Richard
Zdroj: Archives of Internal Medicine; May 1969, Vol. 123 Issue: 5 p554-557, 4p
Abstrakt: The mechanism of injury operative in kidneys affected by glomerulonephritis may be inferred from the pattern of immunoglobulin deposits detected by immunofluorescent examination of such organs and antibodies eluted from them. Studies of tissue from native, glomerulonephritic human kidneys, kidney allografts in such patients, or usually both, indicate that glomerular disease in the allograft is mediated by mechanisms similar to that operative in the native kidney. Moreover, the frequency of clinical and histological disease in allograft patients who had discernible immunoglobulin deposits on their native diseased kidneys suggests a continuation of original disease now afflicting the allograft.
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