| Autor: |
Ross, E. Victor, Roman, Lydia, Rushin, Jeanne M., Cobb, Mark W., Friedman, Kenneth J. |
| Zdroj: |
Archives of Dermatology; November 1992, Vol. 128 Issue: 11 p1499-1502, 4p |
| Abstrakt: |
• BACKGROUND.— Lipoprotein—T-cell interactions are being reported with increasing frequency, and there is evidence that lipoproteins play a role in immunoregulation. We describe a patient with mycosis fungoides and hyperlipidemia who developed xanthomatization in one preexisting plaque. The case is unique in that some of the lipidized cells were atypical T cells. In previously reported cases of mycosis fungoides with dystrophic xanthomatosis, the lipid-containing cells have been identified only as histiocytes. OBSERVATIONS.— Immunopathologic feautures, electron microscopy, and lipid stains of the xanthomatized plaque demonstrated that some of the lipid-laden cells were atypical T cells. CONCLUSIONS.— In mycosis fungoides, malignant T cells may be intimately involved in processing of tissue lipids. We suggest that low-density lipoprotein receptors on activated T cells facilitated the cytoplasmic lipidization in this case.(Arch Dermatol. 1992;128:1499-1502) |
| Databáze: |
Supplemental Index |
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