| Autor: |
Fredericks, Edward J., Kugelman, Thomas P., Kirsch, Neville |
| Zdroj: |
Archives of Dermatology; August 1976, Vol. 112 Issue: 8 p1158-1160, 3p |
| Abstrakt: |
• A motor polyneuropathy developed in a woman with subcorneal pustular dermatosis of 16 years' duration, who had received at least 300 gm of dapsone over a five-year period and 80 gm during the four-month period of progression of her neurologic symptoms. Although the patient believed her muscle power had returned to normal four months after the drug was stopped, a slight peripheral neuropathy remained. Electrodiagnostic and clinical features during the period of greatest weakness and the subsequent 16 months were consistent with a polyneuropathy of the axonal type. The neurotoxicity of dapsone appears to be dosedependent, but the mechanism by which it occurs is unknown.(Arch Dermatol 112:1158-1160, 1976) |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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