DERMATITIS MEDICAMENTOSA: Reaction from Hydrocortisone Suspension Vehicle (Sodium Carboxymethyl Cellulose)

Autor: LOVEMAN, A. B., FLIEGELMAN, M. T.
Zdroj: Archives of Dermatology; October 1956, Vol. 74 Issue: 4 p426-426, 1p
Abstrakt: One case of allergic urticaria has been reported resulting from sensitivity to the suspending agents in the aqueous vehicle of hydrocortisone suspension.* The specific incriminating allergen apparently was not determined.To our knowledge, therefore, the following case is the first to be reported in which a specific component of the hydrocortisone vehicle has been shown to provoke a systemic cutaneous allergic reaction.Report of a CaseA white woman, aged 47, was seen in our office on Sept. 2, 1954, at which time 0.2 cc. of hydrocortisone (Merck's Hydrocortone suspension) was injected into and beneath a synovial cyst of the right fourth finger. Several additional injections were made at two- to three-week intervals, and, according to the patient, after each injection, with the exception of the first, she experienced an extensive hemorrhagic eruption.We were able to reproduce the eruption
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