Synthesis, Isolation and Characterization of Process-Related Impurities in Oseltamivir Phosphate

Autor: Kumar Sharma, Yogesh, Dayal Agarwal, Dau, Bhure, Sudesh, Singh Rathore, Sanjay, Rawat, Chakravir, Mukharjee, Rajendranath
Zdroj: Journal of Chemistry; 2012, Vol. 9 Issue: 1
Abstrakt: Three known impurities in oseltamivir phosphate bulk drug at level 0.1% (ranging from 0.05-0.1%) were detected by gradient reverse phase high performance liquid chromatography. These impurities were preliminarily identified by the mass number of the impurities. Different experiments were conducted and finally the known impurities were synthesized and characterized.
Databáze: Supplemental Index