| Autor: |
Anderson, Matthew Z., Baller, Joshua A., Dulmage, Keely, Wigen, Lauren, Berman, Judith |
| Zdroj: |
Eukaryotic Cell; August 2012, Vol. 11 Issue: 10 p1268-1275, 8p |
| Abstrakt: |
ABSTRACTCandida albicansgrows within a wide range of host niches, and this adaptability enhances its success as a commensal and as a pathogen. The telomere-associated TLOgene family underwent a recent expansion from one or two copies in other CUG clade members to 14 expressed copies in C. albicans. This correlates with increased virulence and clinical prevalence relative to those of other Candidaclade species. The 14 expressed TLOgene family members have a conserved Med2 domain at the N terminus, suggesting a role in general transcription. The C-terminal half is more divergent, distinguishing three clades: clade a and clade ß have no introns and encode proteins that localize primarily to the nucleus; clade ? sometimes undergoes splicing, and the gene products localize within the mitochondria as well as the nuclei. Additionally, TLOa genes are generally expressed at much higher levels than are TLO? genes. We propose that expansion of the TLOgene family and the predicted role of Tlo proteins in transcription regulation provide C. albicanswith the ability to adapt rapidly to the broad range of different environmental niches within the human host. |
| Databáze: |
Supplemental Index |
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