| Autor: |
Ishikura, Kazuaki, Hashizume, Tomomi, Kurita-Ochiai, Tomoko, Makimura, Masaharu, Yamamoto, Masafumi |
| Zdroj: |
Journal of Oral Biosciences; January 2009, Vol. 51 Issue: 1 p1-10, 10p |
| Abstrakt: |
A previous study showed that transcutaneous immunization with the 40-kDa outer membrane protein of Porphyromonas gingivalis(40k-OMP) elicits humoral immunity that protects from abscess induction by P. gingivalis. In this study, we assessed the potential of 40k-OMP as a transcutaneous vaccine against oral P. gingivalisinfection. Transcutaneous immunization of mice with 40k-OMP alone or 40k-OMP plus cholera toxin (CT) elicited 40k-OMP-specific IgG and IgA antibody (Ab) responses in serum and IgG Abs in saliva. These Ab responses were maintained for at least 1 year after immunization, except for serum IgA Abs induced by 40k-OMP alone. Importantly, IgG Abs generated by transcutaneous immunization with 40k-OMP alone, or with 40k-OMP plus CT, inhibited hemagglutinating activity of P. gingivalis. Furthermore, mice transcutaneously immunized with 40k-OMP plus CT, but not 40k-OMP alone, showed significant reduction of alveolar bone loss caused by oral infection with P. gingivaliseven 1 year after immunization. These results suggest that 40k-OMP is an effective transcutaneous vaccine against P. gingivalisinfection and may be an important tool for the prevention of chronic periodontitis. |
| Databáze: |
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