| Autor: |
Pillai, Suthagar, Mahmud, Roziahanim, Lee, Wei Cai, Perumal, Shanmugapriya |
| Zdroj: |
APCBEE Procedia; January 2012, Vol. 2 Issue: 1 p92-96, 5p |
| Abstrakt: |
Nutmeg (Myristica fragransHoutt.) is the seed kernel of inside the fruit. It has been studied to having number of ethnopharmacological properties. Essential oils are secondary metabolites which originated from different parts of plants and made up of volatile compounds. In the present study, the essential oil extracted from nutmeg was investigated for its in vitrocytotoxicity on Vero cell line (normal cell line) and anti-parasitic activity against Toxoplasma gondiiparasite. Nutmeg essential oil showed very low cytotoxic activity against Vero cells with IC50 value of 24.83μg/mL. In the in vitroanti-T.gondiiassay, the oil extract showed significant inhibiting activity with EC50 value of 24.45μg/mL. This result was comparable to the standard drug clindamycin (EC50=16.57μg/mL.). Based on the promising results, nutmeg essential oil may be further studied for its mechanism of action against T.gondiiand to isolate the bioactive compound(s) to treat toxoplasmosis. |
| Databáze: |
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