| Autor: |
Ragia, Georgia, Nikolaidis, Eleftherios, Tavridou, Anna, Arvanitidis, Kostas, Kanoni, Stavroula, Dedoussis, George, Bougioukas, George, Manolopoulos, Vangelis |
| Zdroj: |
Human Genomics; December 2010, Vol. 4 Issue: 6 p1-9, 9p |
| Abstrakt: |
Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene (-786T>Cand 894G>T) enhance endo-thelial dysfunction and have been studied in relation to coronary artery disease (CAD). In the present study, we examined the association of the above polymorphisms with CAD, as well as with myocardial infarction (MI), hypertension, diabetes and smoking in CAD patients. Study subjects consisted of 154 consecutive coronary artery bypass graft (CABG) patients and 155 non-CAD controls. eNOS-786T>Cand 894G>Tpolymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism. The estimated frequencies of the -786Cand 894Talleles did not differ between the two groups (p= 0.46 and p= 0.84, respectively). The prevalence of eNOSpolymorphisms was not associated with MI, hypertension or diabetes in CABG patients; however, we found that the 894TTgenotype and 894Tallele were significantly more frequent in current/past smoker CABG patients (16.7 per cent and 39.6 per cent, respectively) compared with never smoker CABG patients (6.1 per cent and 24.4 per cent, respectively) (p= 0.01 and p< 0.01, respectively). We found no association of eNOS-786Cand 894Tvariant alleles with CAD; however, within CABG patients, a gene-environment interaction was found between the eNOS 894Tallele and smoking. |
| Databáze: |
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