Preservation of Kidneys for Transplantation: An Experimental Study

Autor: BAITZ, THOMAS, HALLENBECK, GEORGE A., SHORTER, ROY G., SCOTT, GERALD W., OWEN, CHARLES A., HUNT, JAMES C.
Zdroj: Archives of Surgery; August 1965, Vol. 91 Issue: 2 p276-287, 12p
Abstrakt: IN THE course of clinical renal transplantation, a period of renal ischemia is inevitable. When living donors are used, the time the kidney is without blood flow can be kept short enough that damage from ischemia is minimal. Use of cadaveric kidneys introduces longer and more variable periods of renal ischemia and makes damage to the kidneys from this cause a more serious problem. The solution to the problem requires, first, that kidneys be obtained in the best possible condition and, second, that once the kidneys are removed, further deterioration be slowed as much as possible until renal blood flow can be established in the recipient. The present study was performed to assess the importance of the duration of the initial period of ischemia in determining subsequent function of canine kidneys and to compare the effectiveness of cooling alone, of cooling in an environment of hyperbaric oxygen, and of normothermic
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