| Autor: |
Wieman, T. Jeffrey, Max, Martin H., Voyles, Carl R., Barrows, George H. |
| Zdroj: |
Archives of Surgery; August 1980, Vol. 115 Issue: 8 p959-961, 3p |
| Abstrakt: |
• Diversion of duodenal contents after gastroenterostomy and vagotomy did not protect 240 laboratory rats from increased risk of gastric carcinoma. They were divided into three groups of 80: group 1 received 0.9 mg of 3-methylcholanthrene injected submucosally into the gastric antrum; groups 2 and 3 had bilateral truncal vagotomy and gastroenterostomy, with carcinogen injected into the gastric submucosa near the anastomosis; group 3 also had total duodenoenteric diversion. Blind histopathologic examination of surviving rats during necropsy eight months later disclosed that cancer had developed in six of 60 (10%) group 1 rats, in 23 of 71 (33%) group 2 rats, and in seven of 27 (22%) group 3 rats. Compared with group 1, groups 2 and 3 had an increased incidence of gastric cancer but did not differ from one another in this regard.(Arch Surg 115:959-961, 1980) |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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