| Autor: |
Chernyi, A.A., Lysov, Yu.P., Il'ychova, I.A., Zibrov, A.S., Shchyolkina, A.K., Borisova, O.F., Mamaeva, O.K., Florentiev, V.L. |
| Zdroj: |
Journal of Biomolecular Structure and Dynamics; December 1990, Vol. 8 Issue: 3 p513-527, 15p |
| Abstrakt: |
AbstractThe paper presents results obtained in conformational analysis of homopolymeric four- stranded poly(dT) · poly(dA) · poly(dA) · poly(dT) DNA helices in which the pairs of strands with identical bases are parallel and have a two-fold symmetry axis. All possible models of base binding to yield a symmetric complex have been considered. The dihedral angles of sugar-phosphate backbones and helix parameters, which are consistent with the minima of conformational energy for four-stranded DNAs, have been determined using the results of optimization of conformational energy calculated at atom-atom approximation. Potential energy is shown to depend on the structure of base complexes and on the mutual orientation of unlike strands. Possible biological functions of four-stranded helices are discussed. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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