| Abstrakt: |
The cardiovascular response to induction of anesthesia with halothane-oxygen, as well as to changes in alveolar concentration from one steady-state level to another, was studied in eight subjects. Heart rate, arterial and right atrial pressures, stroke volume, cardiac output, left ventricular minute work, and total peripheral resistance were recorded beat-to-beat. The last four variables were calculated by a ballistocardiograph-analogue computer system. Induction of anesthesia significantly increased all variables except total peripheral resistance and arterial and right atrial pressures. The last two are the variables conventionally measured during anesthesia and surgery. The response to changing concentration was significantly delayed in time and decreased in magnitude late, as compared to early, in anesthesia administration, which indicated an adaptation to halothane anesthesia. The changes noted during induction in our healthy, normal subjects should be transferred with caution to the situation in the operating room. |
