| Autor: |
Graham, David Y., Brown, Clarence H., Benrey, Jaime, Butel, Janet S. |
| Zdroj: |
JAMA: Journal of the American Medical Association; March 1974, Vol. 227 Issue: 10 p1162-1164, 3p |
| Abstrakt: |
The mechanism of thrombocytopenia associated with mumps was investigated in a case proved by virus isolation. Although an immune mechanism for the thrombocytopenia has been postulated, platelet agglutinins, clot retraction inhibitors, complement-fixing platelet antibodies, or stimulation of platelet factor 3 availability could not be demonstrated in either the presence or absence of mumps-specific antigens. These results suggest that thrombocytopenia is not a consequence of antibodies directed against normal platelets nor against mumps antigen adsorbed to platelets. Rather, it appears that in this disorder, thrombocytopenia may result from a direct action of the virus or a viral antigen-antibody complex on platelets. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
