| Abstrakt: |
TO OUR knowledge, propoxyphene (dextropropoxyphene), a widely used analgesic, has been demonstrated as hepatotoxic in regular clinical use only once.1 We wish to report another case of jaundice apparently caused by this drug.Report of CaseOn Nov 20, 1970, a 47-year-old man who had been suffering from sciatic pains for several years started taking a combination of orphenadrine citrate (35 mg), and paracetamol (450 mg) (Norgesic, as available in Greece), six to eight tablets daily, as well as propoxyphene hydrochloride (65 mg) (Doloxene, as available in Greece), three to four capsules daily. Three days later, he suddenly experienced an extremely severe upper abdominal pain of short duration, followed the next morning by dark urine, clay-colored stools, and gradual development of jaundice. No anorexia, nausea, or other gastrointestinal symptoms preceded or accompanied this episode, and the patient's temperature was normal.On examination, the liver was palpable 1 1/2 finger |
