| Autor: |
Dosik, Harvey, Wachtel, Stephen S., Khan, Farida, Spergel, Gabriel, Koo, Gloria C. |
| Zdroj: |
JAMA: Journal of the American Medical Association; November 1976, Vol. 236 Issue: 22 p2505-2508, 4p |
| Abstrakt: |
A number of patients with a male phenotype and a female (46XX) karyotype have been described. Although there is little or no evidence for the presence of a Y chromosome in their cells, these individuals resemble patients with Klinefelter syndrome (47XXY). Using a new serological assay for the presence of H-Y antigen, a cell surface component associated with the Y chromosome, we have demonstrated the presence of Y-chromosomal genes in a 46-year-old man with an XX karyotype. In addition, using standard cytological techniques, we have located a minor population of XXY cells as well as cells bearing an abnormal chromosome 17 among the blood leukocytes of this individual.(JAMA 236:2505-2508, 1976) |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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