Single-Dose Amoxicillin Therapy for Urinary Tract Infection: Multicenter Trial Using Antibody-Coated Bacteria Localization Technique

Autor: Rubin, Robert H., Fang, Leslie S. T., Jones, Stephen R., Munford, Robert S., Slepack, J. M., Varga, Patricia A., Onheiber, Linda, Hall, Catherine L., Tolkoff-Rubin, Nina E.
Zdroj: JAMA: Journal of the American Medical Association; August 1980, Vol. 244 Issue: 6 p561-564, 4p
Abstrakt: Urine specimens from 134 women with acute, uncomplicated urinary tract infection at three medical centers were examined by the antibody-coated bacteria (ACB) assay. Patients with negative assays (suggesting bladder infection alone) were randomized to receive either a single 3-g oral dose of amoxicillin trihydrate or conventional ten-day courses of sulfamethoxazole-trimethoprim or oral ampicillin sodium. Comparable results were obtained with the three regimens for ACB-negative infection: 90% eradication of the original organism with single-dose amoxicillin, 100% with sulfamethoxazole-trimethoprim, and 96% with ampicillin. The overall incidence of ACB positivity was 32.1%, ranging from 8% to 63% at the three institutions. This difference seemed to be related to the ease of access to medical care: women with easy access having low rates of ACB positivity and those with poor access having high rates.(JAMA 244:561-564, 1980)
Databáze: Supplemental Index