| Autor: |
Skubitz, Keith M., Craddock, Philip R., Weisdorf, Daniel J., Niedel, James E., LeBien, Tucker W., Kersey, John H., Brunning, Richard D., Parkin, Janet L., Flynn, Patrick J., Hammerschmidt, Dale E. |
| Zdroj: |
JAMA: Journal of the American Medical Association; December 1983, Vol. 250 Issue: 21 p2957-2960, 4p |
| Abstrakt: |
A 50-year-old man had chronic myelogenous leukemia and entered a blast crisis that was both morphologically and histochemically lymphoid. The blasts contained terminal deoxyribonucleotidyl transferase and expressed lymphoblastic leukemia-associated antigen. He rapidly entered remission with vincristine sulfate and prednisone therapy. Nevertheless, his blasts displayed a marker generally considered unique to myeloid cells: they selectively bound the granulocyte chemotaxin N-formyl-Met-Leu-Phe. In addition, some cells contained granules resembling those of basophils or mast cells. Such mixed myeloid-lymphoid features in chronic myelogenous leukemia blast cells may reflect malignant transformation of a stem cell capable of both myeloid and lymphoid differentiation, or they may reflect the dedifferentiation as a feature of malignant change.(JAMA 1983;250:2957-2960) |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
