Role of Angiotensin II in the Pathogenesis of Hyperdipsia in Chronic Renal Failure

Autor: Yamamoto, Toshihide, Shimizu, Masanori, Morioka, Masahiro, Kitano, Mitsuo, Wakabayashi, Hirokazu, Aizawa, Nobuyuki
Zdroj: JAMA: Journal of the American Medical Association; August 1986, Vol. 256 Issue: 5 p604-608, 5p
Abstrakt: The relation of thirst to the renin-angiotensin system was examined in 38 patients with chronic renal failure receiving hemodialysis treatment. They were classified into three groups, ie, group 1(19 patients), no or modest thirst; group 2 (13 patients), moderate thirst; and group 3 (six patients), excessive thirst. The plasma renin activity, plasma angiotensin II levels, and interdialytic weight gains of groups 1 to 3 significantly increased in a progressive manner with intensity of thirst. The hyperdipsia experienced by four patients in group 3 ameliorated after administration of an angiotensin-converting-enzyme inhibitor. The hyperdipsia of some patients with chronic renal failure therefore appears to be mediated by increased production of endogenous angiotensin II.(JAMA 1986;256:604-608)
Databáze: Supplemental Index