| Autor: |
Pottage, John C., Benson, Constance A., Spear, Joel B., Landay, Alan L., Kessler, Harold A. |
| Zdroj: |
JAMA: Journal of the American Medical Association; November 1988, Vol. 260 Issue: 20 p3045-3048, 4p |
| Abstrakt: |
Human immunodeficiency virus (HIV)—related thrombocytopenia has been well described and requires therapy in about one half of the patients. Conventional modes of therapy with prednisone, danazol, immunoglobulin, and/or splenectomy have not been uniformly successful. We have administered zidovudine to three patients with HIV-related thrombocytopenia. All three patients responded with a sustained increase in their platelet counts, despite discontinuation of conventional therapy. Interruption of zidovudine therapy was associated with a decrease in platelet count. Concomitant with the elevation in platelet count with zidovudine therapy, there was a reduction in the circulating p24 antigen levels. Whether the elevations in the platelet count in these patients with HIV-related thrombocytopenia is due to the antiviral effect of zidovudine is unknown. It is clear that further studies examining the prospective use of zidovudine in the treatment of HIV-related thrombocytopenia are indicated.(JAMA 1988;260:3045-3048) |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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