| Autor: |
Arkwright, Peter D., Chase, Jennifer M., Babbage, Sarah, Pravica, Vera, David, Timothy J., Hutchinson, Ian V. |
| Zdroj: |
The Journal of Allergy and Clinical Immunology; August 2001, Vol. 108 Issue: 2 p281-284, 4p |
| Abstrakt: |
Background:Atopic dermatitis (AD) is associated with hyperresponsiveness of lymphocytes to allergens. In acute AD only TH2-type lymphocytes are activated, whereas in more chronic forms of AD, the activity of both TH1- and TH2-type lymphocytes increases. IL-10 and transforming growth factor β1(TGF-β1) are immunosuppressive cytokines that inhibit the activity of both THcell types in human subjects. Objective:The aim of this study was to determine whether children with moderately severe chronic AD had IL10or TGFB1genotypes known to be associated with low cytokine production. Methods:Using amplification refractory mutation screening PCR, we examined TGFB1and IL10gene polymorphisms, which are known to affect cytokine production, in 68 children with moderately severe AD and in 50 nonatopic children. Results:The odds ratio of children with AD having a low TGFB1producer genotype was 4.8 (95% CI, 2.4-9.7) compared with the control subjects (P< .0001). There were no differences in the frequency of IL10gene polymorphisms between groups. Conclusion:TGFB1genotype may partly explain the strong genetic predisposition to AD. (J Allergy Clin Immunol 2001;108:281-4.) |
| Databáze: |
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