| Autor: |
Teng, YK Onno, Wheater, Gillian, Hogan, Vanessa, Stocks, Philip, Levarht, EW Nivine, Huizinga, Tom, Toes, Rene, van Laar, Jacob |
| Zdroj: |
Arthritis Research & Therapy (formerly Arthritis Research); April 2012, Vol. 14 Issue: 2 pR57-R57, 1p |
| Abstrakt: |
B-cell depletion has become a common treatment strategy in anti-TNF-refractory rheumatoid arthritis (RA). Although the exact mechanism of how B-cell depletion leads to clinical amelioration in RA remains to be elucidated, repetitive treatment with B-cell-depleting agents leading to long-term B-cell depletion has been reported to be beneficial. The latter has led to the hypothesis that the beneficial effects of B-cell depletion might act through their influence on pathogenic autoreactive plasma cells. |
| Databáze: |
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