| Autor: |
Callahan, Daniel J., Liu, Wenge, Li, Xinghai, Dreher, Matthew R., Hassouneh, Wafa, Kim, Minkyu, Marszalek, Piotr, Chilkoti, Ashutosh |
| Zdroj: |
Nano Letters; 20240101, Issue: Preprints |
| Abstrakt: |
To address the limited tumor penetration of nanoparticle drug delivery vehicles, we report the first pH-responsive polypeptide micelle that dissociates at the low extracellular pH of solid tumors. This histidine-rich elastin-like polypeptide block copolymer self-assembles at 37 °C into spherical micelles that are stabilized by Zn2+and are disrupted as the pH drops from 7.4 to 6.4. These pH-sensitive micelles demonstrate better in vivo penetration and distribution in tumors than a pH-insensitive control. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
