| Autor: |
Reitberg, Donald P., Weiss, Sidney L., del Rio, Eve |
| Zdroj: |
Drug Information Journal; April 2005, Vol. 39 Issue: 2 p119-124, 6p |
| Abstrakt: |
Experts in evidence-based medicine consider single-patient trials or “n-of-1” studies to be the highest form of evidence for making individual patient drug treatment decisions. Single-patient trial-based risk management programs for chronic care drugs with recognized safety risks would improve risk/benefit by more reliably identifying individual patients who do not receive benefit and/or who experience undue short-term adverse events. The widespread use of single-patient trials would also generate a continuously expanding database of prospectively documented effectiveness and safety outcomes that would support population and subgroup risk/benefit assessments, leading to improved prescribing information. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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