| Autor: |
Carey, P. F., Spurling, N. W. |
| Zdroj: |
Drug Information Journal; January 1994, Vol. 28 Issue: 1 p203-211, 9p |
| Abstrakt: |
A three-stage maximum repeatable dose (MRD) protocol is described in which the MRD is established by dose incrementation, followed by administration of this dose for at least seven days, with the final stage being single dose administration of the doses anticipated for the one-month studies. The toxicokinetic measurements which are made in support of this protocol are illustrated with data from studies in the rat, and examples are given where this information may be used in the better design of chronic toxicity studies. The applications and limitations of the protocol are discussed in the light of experience gained with several compounds over the past few years. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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