| Autor: |
Dixon, W. J., Fotheringham, N. |
| Zdroj: |
Drug Information Journal; July 1993, Vol. 27 Issue: 3 p741-751, 11p |
| Abstrakt: |
Staircase bioassays are compared to the classical design using tests at fixed levels with a fixed sample size. With comparable advance information on location and scale, the staircase procedures can attain efficiency in sample size, for given accuracy, four or five times that of the classical design. The penalty in increased time for carrying out the experiment need not be more than a factor or two. Examples from the literature illustrate this increased efficiency in the use of animals, and an iterative method is presented for estimating the standard error of the estimate and the standard deviation of the thresholds from multiple short up-and-down series used in factorially designed experiments. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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