| Autor: |
CHOCKALINGAM, PRIYA, JAEGGI, EDGAR T., RAMMELOO, LUKAS A., HAAK, MONIQUE C., ADAMA van SCHELTEMA, PHEBE N., BREUR, JOHANNES M.P.J., BARTELINGS, MARGOT M., CLUR, SALLY-ANN B., BLOM, NICO A. |
| Zdroj: |
Journal of Rheumatology; December 2011, Vol. 38 Issue: 12 p2682-2685, 4p |
| Abstrakt: |
OBJECTIVE: To study the clinical course and outcome of fetal sinus bradycardia (SB) due to maternal antibody-induced sinus node dysfunction. METHODS: We reviewed the maternal, prenatal, and postnatal findings of fetuses with SB associated with elevated maternal anti-SSA/Ro and anti-SSB/La antibodies. RESULTS: Of the 6 cases diagnosed prenatally, 3 had isolated SB persisting after birth and had a good prognosis. Three fetuses with SB and severe myocardial involvement (congenital complete heart block and/or endocardial fibroelastosis) succumbed in utero in spite of treatment. Postmortem histopathology in 1 fetus showed inflammatory destruction of the sinus and atrioventricular nodes. SB was detected incidentally in a 7-year-old girl. She had intermittent heart block with progressive sinus arrest requiring permanent pacemaker. CONCLUSION: Fetal SB associated with maternal autoantibodies may persist in childhood, with a good prognosis in the absence of widespread cardiac involvement. |
| Databáze: |
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