| Autor: |
Parker, Rachel M.C, Barnes, Janine M, Ge, Jian, Barber, Peter C, Barnes, Nicholas M |
| Zdroj: |
Journal of the Neurological Sciences; December 1996, Vol. 144 Issue: 1-2 p119-127, 9p |
| Abstrakt: |
Autoradiographic binding studies using the 5-HT3(5-hydroxytryptamine3) receptor radioligand, [3H]-(S)-zacopride (0.5 nM), identified a heterogeneous distribution of specific binding sites (defined by granisetron, 1 μM) throughout the human brain. Highest radiolabelled 5-HT3receptor densities were detected in discrete nuclei within the brainstem (nucleus tractus solitarius, area postrema, spinal trigeminal nerve nucleus; 50–200 fmol/mg tissue equivalent) with more modest levels of expression in the forebrain (e.g. hippocampus, nucleus accumbens, putamen, caudate; 4–17 fmol/mg tissue equivalent). Within the hippocampal formation, radiolabelled 5-HT3receptors were differentially distributed with highest levels in the granule cell layer of the dentate gyrus. |
| Databáze: |
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