| Autor: |
Bussfeld, Delia, Bacher, Michael, Moritz, Annette, Gemsa, Diethard, Sprenger, Hans |
| Zdroj: |
Immunobiology; December 1997, Vol. 198 Issue: 1-3 p291-298, 8p |
| Abstrakt: |
Infection of human monocytes with influenza A virus induces a broad range of proinflammatory cytokines and mononuclear cell attracting chemokines before the infected cells, undergo apoptosis. The underlying mechanisms by which the corresponding genes are transcriptionally initiated after virus infection are still poorly understood. Activation of NF-κB seems to play an important role in the regulation of many proinflammatory cytokine genes, but cannot be the only mechanism, since several cytokine genes lack respective binding sites in their promoter regions. Therefore, we additionally investigated other transcription factors of possible importance such as CREB, CTF, OTF-1, and OTF-2. |
| Databáze: |
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