| Autor: |
Sanz-Ortega, J., Sanz-Esponera, J., Caldes, T., Gomez De La Concha, E., Sobel, M.E., Merino, M.J. |
| Zdroj: |
Pathology - Research and Practice; January 1996, Vol. 192 Issue: 12 p1206-1210, 5p |
| Abstrakt: |
The APCIMCC gene (Familial Adenomatous Polyposis) at 5g21 plays a role in colon cancer carcinogenesis. LOH at this locus has also been described in gastric cancer and preneoplastic lesions. The APC locus has been recently related to a cell surface adhession molecule and its alteration may favour metastatic dissemination. LOH at 5g21 has been associated with poor prognosis in other tumors such as lung cancer. Thirty-six gastric cancers were evaluated for LOH at 5g21 with 2 polymorphic markers from microdissected paraffin-embedded material. All tumors were classified by stage, histologic type, degree of differentiation and survival rates. In 4 cases, intestinal metaplasia cells in the adjacent mucosae were also microdissected. Six cases of moderate-severe gastric dysplasia were also added to the study. LOH was determined in 84 % o f the informative cases o f GC, affecting both early and advanced stages o f disease. Genomic instability was assessed in S cases, 3 o f them associated with LOH. The only case of gastric cancer that did not show LOH or instability at 5g21 was a stage II, poorly differentiated intestinal carcinoma without evidence o f recurrence after a 36 month follow-up period (the mean survival rate in our series was 28.3 % at 36 months). We also found LOH in 216 dysplastic lesions and 114 intestinal meta plasias. Our data show that LOH at 5g21 is frequent in gastric cancer and is also present in intestinal metaplasia and dysplastic lesions. LOH at this locus is not a prognostic factor in GC in our study, due to the high incidence of LOH that we found. |
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