| Autor: |
Siegmund, Kimberly D., Whittemore, Alice S., Thomas, Duncan C. |
| Zdroj: |
Journal of the National Cancer Institute. Monographs; December 1999, Vol. 1999 Issue: 26 p43-43, 1p |
| Abstrakt: |
BACKGROUND: The objectives of a family-based disease registry range from characterizing measured genetic factors and gene-environment interaction effects to detecting novel susceptibility genes. Gathering complete information on exposure and disease status in all family members for a sample of affected subjects (probands) to address these diverse objectives would be prohibitively expensive. METHODS: Multistage sampling can be used to design an efficient family-based disease registry. At each stage, the probands are classified on the basis of previously collected data, and a subsample is selected for more detailed observation. The design can be optimized to minimize the variance of any of the model parameter estimates, subject to a constraint on the total sample size. RESULTS: We describe the basic statistical theory and its application to a four-stage sampling scheme proposed for the Cooperative Family Registry for Epidemiologic Studies of Colorectal Cancer at the University of Southern California. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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