| Autor: |
Kosmehl, H., Berndt, A., Katenkamp, D., Mandel, U., Bohle, R., Gabler, U., Celeda, D. |
| Zdroj: |
Pathology - Research and Practice; November 1995, Vol. 191 Issue: 11 p1105-1113, 9p |
| Abstrakt: |
The tissue formation process in nodular palmar fibromatosis (Morbus Dupuytren) was investigated by the demonstration of fibronectin splice variants (ED-A and ED-B fibronectin), de novo glycosylated fibronectin and laminin isoforms (A, M, B 1, B2, s chains) in association to the proli f erative activity (Ki-67 antigen) and the occurrence o f myofibroblast phenotype (α-smooth muscle actin, desmin). The proliferative noduli of the fibromatosis were characterized by a diffuse immunostaining for alpha-smooth muscle actin, and single cells positive for desmin and the Ki-67 antigen. In contrast to the surrounding aponeurosis as extracellular matrix, components of the whole proliferative noduli were defined: ED-A, ED-B and de novo glycosylated fibronectin, B1 and B2 laminin chain, tenascin and collagen type IV. The demonstration of the A and M laminin chain was restricted to a few cells of the proliferative noduli. S laminin could be visualized in the majority of palmar aponeurosic fibroblasts. As revealed by mRNA, in situ hybridization a de novo synthesis of fibronectin could only be detected within proliferative noduli. |
| Databáze: |
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