| Autor: |
Fee, M., Tobin, B., Magee, H., Harrison, M., Gorey, T., Dervan, P.A. |
| Zdroj: |
Pathology - Research and Practice; January 1996, Vol. 192 Issue: 9 p919-924, 6p |
| Abstrakt: |
Estimation of oestrogen receptors (ER) in breast carcinoma has important therapeutic and prognostic implications. The dextran-coated charcoal (DCC) biochemical technique is being replaced in many institutions by immunohistochemical techniques. The aim o f this study was to assess the level o f agreement between ER counts in frozen and paraffin sections. Ninety-seven infiltrating breast carcinomas were studied immunohistochemically, for ER in frozen and paraffin sections. Cases were classified as ER-positive i f10% o f the tumour cells were positive. Both techniques gave a high level o f correlation and agreement. There was complete agreement in classifying cases as ER-positive or ER-negative. ER estimation on only one case was outside 2SD o f complete agreement. Oestrogen-receptor content can be assayed satisfactorily in paraffin sections and offers many advantages over the frozen section technique. |
| Databáze: |
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