Recurrent Phyllodes Tumor in a Man

Autor: Kahán, Zsuzsanna, Tószegi, Anna M., Szarvas, Ferenc, Gaizer, György, Baradnay, Gyula, Ormos, Jenõ
Zdroj: Pathology - Research and Practice; January 1997, Vol. 193 Issue: 9 p653-658, 6p
Abstrakt: The case of a 35-year-old man with a borderline-type cystosarcoma phyllodes is presented. Four years after the primary excision of the tumor, wide excision of a local recurrence and postoperative radiotherapy were performed. No repeated relapse was observed during a 5-year follow-up. Neither significant endocrine changes nor genetic alteration could be proven. However, a slightly increased SHBG concentration was detected, resulting in a decreased biologically available androgen level reduced testosterone/SHBG index. This phenomenon might be a consequence of the chronic liver disease of the patient due to his type II diabetes mellitus and alcohol abuse. In addition to the conventional histopathological examinations, immunohistochemical and electron-microscopic investigations were carried out on tissue sections, and the steroid receptors, EGF receptors and EGF-like activity of the tumor were also studied.
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