| Autor: |
Montironi, Rodolfo, Diamanti, Lucilla, Santinelli, Alfredo, Galetti-Prayer, Tommaso, Zattoni, Filiberto, Selvaggi, Francesco Paolo, Pagano, Francesco, Bono, Aldo Vittorio |
| Zdroj: |
Pathology - Research and Practice; January 1999, Vol. 195 Issue: 4 p201-208, 8p |
| Abstrakt: |
The likelihood of finding organ-confined untreated prostate cancer (PCa) by pathological examination at the time of radical prostatectomy (RP) is only 50% in patients with clinically organ-confined disease. In addition, tumour is present at the resection margin in approximately 30% of clinical T2 (clinical stage B) cases. The issue of clinical “understaging” and of resection limit positivity have led to the development of novel management practices, including “neoadjuvant” hormonal therapy (NHT). The optimal duration of NHT is unknown. We undertook the present analysis to evaluate the effect of NHT on pathologic stage of PCa and resection limit status in patients with prostate cancer and treated with total androgen ablation either for three or six months before RP. |
| Databáze: |
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