| Autor: |
Calore, E.E., Weg, R., Haraguchi, M., Calore, N.M.P, Cavaliere, M.J., Sesso, A. |
| Zdroj: |
Experimental and Toxicologic Pathology; August 2000, Vol. 52 Issue: 4 p357-363, 7p |
| Abstrakt: |
The chronic administration of S. occidentalisseeds was found to induce a mitochondrial myopathy in hens. This study was undertaken to determine if the chronic treatment with S. occidentalisseeds of rats (as a mammalian model) would induce a mitochondrial myopathy similar to those described in humans and to determine if the histological changes could be correlated with the amount of ingested seeds. Twenty-one days old rats were fed S. occidentalisseeds at different diet concentrations (1, 2, 3%). Rats fed 1% S. occidentalisseeds had only a few COX-negative muscle fibbers in the pectoralis major muscle. Rats fed 3% Senna occidentalisseeds had a greater number of COX-negative fibbers. Rats fed 2% had an intermediate number of COX-negative fibbers. Activity of SDH and NADH-tr were decreased in rats of groups 2% and 3%. Our data indicate that a progressive mitochondrial metabolism impairment can be produced in rats fed S. occidentalisseeds and that this impairment can be correlated with the amount of ingested seeds. |
| Databáze: |
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